Endocrine Abstracts

Background: Diabetes insipidus (DI) is characterized by polyuria and consequently thirst and polydipsia. Excessive water intake can also cause polyuria, i.e. primary polydipsia. It is of utmost importance to differentiate between the two disorders since the treatment is different.Aims: To study the clinical value of the standard 8-hour as well as an extended water deprivation test in patients with polyuria and polydipsia.P...

Background: Patient’s with Addison’s disease (AD) have increased morbidity and mortality. Cardiovascular disease is considered the leading cause of death. The aim was to study cardiovascular risk factors in patients with AD.Methods: In a single-centre, case–ontrol study 78 patients (52 women) with AD were compared to 78 controls, matched for gender, age, BMI, and smoking habits. Serum was collected in a fasting state for measurement of lip...

Background: Clinical features of acromegaly develop insidiously and the diagnosis is often delayed. However, diagnostic delay (DD) in acromegaly has not been systematically investigated. Our primary aim was to investigate DD in a nationwide cohort of patients with acromegaly. Secondary aim was to study the impact of DD on morbidity and mortality.Methods: Adult patients diagnosed with acromegaly between 2001 and 2013 were identified in the Swedish Nationa...

Background: Patients with Cushing’s syndrome (CS) in remission often suffer from impaired quality of life and cognitive dysfunction. Mental fatigue is characterized by mental exhaustion which appears especially during sensory stimulation or following mentally strenuous tasks. Other typical features are long recovery time for restoration of mental energy, irritability, impaired memory and concentration and sensitivity to stress, light and noise. The primary aim of this stu...

Context: Patients with adrenal insufficiency (AI) have excess mortality and morbidity, mainly due to cardiovascular diseases. The mechanisms for this is unclear.Objective: To assess cardiovascular structure and function in AI patients on conventional replacement therapy and after switching to once-daily, modified-release hydrocortisone (OD-HC).Methods: The analysis included 17 adult AI patients (11 with primary AI, 7 with secondary...

Objective: Patients who receive ≥5 mg prednisolone per day, for more than 2–3 weeks, are at risk of developing glucocorticoid (GC) induced adrenal insufficiency (tertiary adrenal insufficiency, 3° AI). The aim of this study was to a) determine the prevalence of GC use in doses that are associated with development of 3° AI, b) assess prescription pattern of short and long-term GC treatment in adults and children, and c) investigate the indication for the GC...

Background: Carpal tunnel syndrome (CTS) is common in patients with acromegaly, with a reported prevalence of 19–64%. We have studied CTS in a large national cohort of patients with acromegaly, and the temporal relationship between the diagnosis of the two diseases.Methods: Retrospective nationwide cohort study including patients diagnosed with acromegaly in Sweden between 2005 and 2017. Patients with acromegaly were identified in the Swedish Natio...

Background: Patients with Cushing’s syndrome (CS) in long-term remission have impaired cognitive function. Cerebrospinal fluid (CSF) biomarkers are important diagnostic tools in the work-up of patients with cognitive impairment. The aim of this study was to analyze biological markers in CSF from patients with CS in remission. Owing to the overlapping similarities between patients with CS and dementia, i.e. cognitive dysfunction and hypercortisolemia, the main hypothesis w...

Background: ACTH-independent Cushing syndrome (CS) accounts for 15–20% of endogenous CS. Approximately 10% of these patients have bilateral adrenal lesions where the differential diagnoses are primary bilateral adrenal macronodular hyperplasia (PBMAH), primary pigmented nodular adrenal disease (PPNAD), bilateral cortisol producing adenomas or a unilateral cortisol producing adenoma with a contralateral nonfunctioning adenoma. Also, the prevalence of subclinical CS is high...

ContextPrimary aldosteronism (PA) is the most common cause of secondary hypertension. Yet, the incidence of PA in the population has not been studied.ObjectiveTo estimate the incidence of PA in western Sweden.Design and methodsPatients who had received a diagnostic code for PA between 1987 and 2016 were identified in the Swedish National Patient Registry. Assessme...